Returning leads Leon Kennedy (Resident Evil 4) and Chris Redfield (Resident Evil 5) will both be playable Characters in Resident Evil 6. Both Chris Redfield and Leon Kennedy will have new characters as partners: Piers Nivans and Helena Harper, respectively. The third pair of playable characters is Sherry Birken and Jake Muller. Ada Wong will also be a playable character.
Leon's Campaign: In United States - the President is about to "come clean" over the incident in Raccoon City in a seminar at Ivy University, Tall Oaks, when he himself mutates into a zombie. A man at the university guides Leon S. Kennedy and his partner, Helena Harper, through the campus in the search for his missing daughter, Liz.
Jake's Campaign: In the Eastern European state of Edonia, Jake Muller, the son of eugenicist; virologist and bioterrorist Albert Wesker, flees from the authorities during a bioterrorist attack. During Jake's adventure, he partners up with Sherry Birkin, daughter of the deceased Dr. William Birkin - a research partner of Albert's. They are chased by a Tyrant-like creature called Ustanak.
Chris' Campaign: After the deaths of a number of soldiers under Chris' command at least six months prior in Edonia. Chris left the B.S.A.A. and became a drunken wreck, before being convinced by Piers Nivans to come back and finish his mission to end bioterrorism, Chris reluctantly returns to the organization.
Ada's Campaign: Ada will get her own campaign unlocked following the completion of the 3 main campaigns and will consist of Ada's perspective on Leon, Chris, and Jake's storyline . It will also be unique in that it is the only campaign to feature solo play. Ada's campaign will also be primarily focused on puzzles.